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Downstream Process Development Lead
PROTEINEACairo, Cairo, EG21 hours ago
Job descriptionTechnically lead downstream projects and supervise process development and new methods. Responsible for overseeing and maintaining equipment and technologies. Demonstrate expertise in protein purification techniques (affinity, size exclusion, ion exchange, hydrophobic interaction chromatography using AKTA systems), filtration, and biochemical / biophysical characterization. Execute routine purifications and perform analyses (SDS-PAGE, SE-HPLC) to develop, validate, and transfer analytical methods. Support method troubleshooting and guides purification method development. Develop novel and standard purification processes (mg to gram scale) ensuring virus, endotoxin, host cell protein, and DNA clearance. Optimize process performance through small-scale and pilot studies, applying DOE. Assist in designing and optimizing downstream purification (ultrafiltration, chromatography, virus clearance). Perform routine purification and equipment maintenance. Conduct literature reviews for process improvement. Design, execute, and analyze experiments using DoE principles and statistical software (JMP, Minitab). Analyze, interpret, and document experimental data. Collaborates with cross-functional teams and contributes to technical reports, SOPs, and presentations. Maintains a safe lab environment (GLP). Provides training and supervision to other team members. Stay up to date on new practices relevant to the industry. Educational Background : MSc or PhD in biochemistry, biotechnology, chemical engineering, or a related field. Extensive hands-on protein purification experience (AKTA : affinity, SEC, IEX, HIC). Analytical method development expertise (SDS-PAGE, SEC-HPLC). DoE knowledge (JMP, Minitab). Downstream process design / optimization experience (mg to gram scale, impurity clearance). Equipment operation / maintenance skills. Project leadership / mentoring experience. Strong documentation / communication abilities (reports, SOPs, presentations). Thorough GLP understanding. Effective cross-functional collaboration skills (R&D, QC, manufacturing). Strong written communication skills in English. Process scale-up experience. Proficiency in advanced analytical techniques. Ability to conduct literature reviews and innovation. Regulatory knowledge in GMP. Skilled in troubleshooting purification and analytical methods. Analytical Thinking Continuous Learning Problem Solving Detail Orientation Results Orientation Team Work Time Management Ownership – We take initiative and follow through on our commitments. Curiosity – We ask questions, seek understanding, and never stop learning. Respect – We value diverse perspectives and treat everyone with dignity. Integrity – We do the right thing, even when it’s hard. Collaboration – We work together openly and support each other too. Adaptability – We stay flexible and adjust quickly to change. Evidence-Based Analysis – We make decisions grounded in data, not guesswork. Top-tier salary, in Egypt with USD-based payment; Equity upside, real ownership, rare in academia / corporate settings; Global scale, local leadership, Egypt is the engine room of our innovation; Mission-driven science, solving challenges relevant to MENA and the world! Perks designed for life, not just work, our team deserves more than just a job, so we continue to build an environment where we can do our best work and live a supported life through our journey with Proteinea.
As a Downstream Process Development Lead at Proteinea , you will oversee downstream process development, focusing on protein purification, process optimization, and technology implementation. This role involves leading projects, developing and validating methods, ensuring equipment functionality, and collaborating with cross-functional teams to deliver scalable, high-quality purification processes in a GLP-compliant laboratory environment.
]Hiring Journey Overview
We keep things flexible, so steps might sometimes be adjusted, merged, or skipped; here’s what to expect from our hiring process :
- Resume Screening : Our team reviews your resume to match your skills with the role.
- Talent Screening Interview : An online video call to assess your potential for success and share with you a little bit more about Proteinea!
- Interviews : The interviews will be mainly with the team to dive deeper into your experience and skills and see how fit you're to the role.
- Culture-Fit Interview : The last step where you meet our CEO and see how well you align with our team culture and values.
You will be invited to visit our office at any point during the process; we always love connecting in person with our potential future team members!
]About Proteinea
Proteinea is a pioneering TechBio company that is redefining protein engineering through artificial intelligence and computational biology. Headquartered in Cairo, Egypt, with offices in the USA, Germany, UAE and KSA, we specialize in designing next-generation antibody therapeutics using AI-driven platforms.
Our proprietary technologies, including our industry-leading protein language model, Ankh, enable us to develop precision-engineered biologics faster, at lower costs, and with higher success rates than traditional methods.
At Proteinea , we integrate cutting-edge AI models, proprietary datasets, and state of the art wet-lab validation to accelerate the discovery and development of therapeutic proteins. Our work focuses on engineering antibodies with optimized efficacy, safety, and manufacturability.
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Development • Cairo, Cairo, EG
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